new PEGylation alternatives
THERAPEUTICS REIMAGINED
Combining the power of computational science, synthetic chemistry and biology, BHS introduces a new era of therapeutic tools that overcome the limitations of PEGylation technology. Biohybrid Solutions’™ innovators have developed a proprietary understanding of structure-function interactions between polymers and biological molecules, resulting in new synthetic processes, materials, applications, and therapies. To date, we have created thousands of different NanoArmored™ proteins™ for a variety of therapeutic applications.
BHS-001
Program: OPH Prophylactic
Indication: Nerve agent exposure
Stage: Preclinical development and advanced testing
- preclinical
BHS-002
Program: GI Enzyme Replacement Therapy
Indication: Pancreatic enzyme insufficiency
Phase: Development
- Development
BHS-003
Program: Enabling Immunotherapy
Indication: IgG
Phase: Development
- Research
OPPORTUNITIES IN THERAPEUTICS
Imagine a new alternative to PEGylation that enables more patient friendly routes of administration, reduced immunogenicity and improved pharmacodynamics and pharmacokinetics.
New peptites or protein delivery platforms and therapeutics (e.g. oral, devices)
Thermostable proteins or peptides
Sensing/responsive proteins/peptides
Novel linker/conjugation chemistries
Alternative to PEGylation to enable lifetime extension
Controlled response for better efficacy